Humoral signatures of protective and pathological SARS-CoV-2 infection in children
Name
Bartsch Wang Nature Med 2021.pdf
Description
Accepted version
Size
12.95 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Bartsch, Yannic C.
Wang, Chuangqi
Zohar, Tomer
Fischinger, Stephanie
Atyeo, Caroline
Burke, John S.
Kang, Jaewon
Edlow, Andrea G.
Fasano, Alessio
Baden, Lindsey R.
Date Issued
February 2021
Journal
Nature Medicine
Publisher
Springer Science and Business Media LLC
Citation
Bartsch, Yannic C. et al. "Humoral signatures of protective and pathological SARS-CoV-2 infection in children." Nature Medicine 27, 3 (February 2021): 454–462. © 2021 The Author(s)
Version
Author's final manuscript
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread relentlessly, associated with a high frequency of respiratory failure and mortality. Children experience largely asymptomatic disease, with rare reports of multisystem inflammatory syndrome in children (MIS-C). Identifying immune mechanisms that result in these disparate clinical phenotypes in children could provide critical insights into coronavirus disease 2019 (COVID-19) pathogenesis. Using systems serology, in this study we observed in 25 children with acute mild COVID-19 a functional phagocyte and complement-activating IgG response to SARS-CoV-2, similar to the acute responses generated in adults with mild disease. Conversely, IgA and neutrophil responses were significantly expanded in adults with severe disease. Moreover, weeks after the resolution of SARS-CoV-2 infection, children who develop MIS-C maintained highly inflammatory monocyte-activating SARS-CoV-2 IgG antibodies, distinguishable from acute disease in children but with antibody levels similar to those in convalescent adults. Collectively, these data provide unique insights into the potential mechanisms of IgG and IgA that might underlie differential disease severity as well as unexpected complications in children infected with SARS-CoV-2.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/s41591-021-01263-3
