The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation
Name
adhm.201901410.pdf
Description
Published version
Size
1.76 MB
Format
Unknown
Checksum (MD5)
201bf259a5eb317d01b7d4a2506bd22b
Author(s)
Coughlin, Mark F.
Kamm, Roger D.
Date Issued
January 2020
Journal
Advanced Healthcare Materials
Publisher
Wiley
Version
Final published version
Abstract
© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Powerful experimental tools have contributed a wealth of novel insight into cancer etiology from the organ to the subcellular levels. However, these advances in understanding have outpaced improvements in clinical outcomes. One possible reason for this shortcoming is the reliance on animal models that do not fully replicate human physiology. An alternative in vitro approach that has recently emerged features engineered microfluidic platforms to investigate cancer progression. These devices allow precise control over cellular components, extracellular constituents, and physical forces, while facilitating detailed microscopic analysis of the metastatic process. This review focuses on the recent use of microfluidic platforms to investigate the mechanism of cancer cell extravasation.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.201901410
