Characterization of reaction enthalpy and kinetics in a microscale flow platform
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d0re00304b.pdf
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Author(s)
Ladosz, Agnieszka
Kuhnle, Christina Catharina
Jensen, Klavs F
Date Issued
September 2020
Journal
Reaction Chemistry & Enigineering
Publisher
Royal Society of Chemistry (RSC)
Citation
Ladosz, Agnieszka et al. "Characterization of reaction enthalpy and kinetics in a microscale flow platform." Reaction Chemistry & Enigineering 5, 11 (September 2020): doi.org/10.1039/D0RE00304B. © 2020 Royal Society of Chemistry 2020
Version
Final published version
Abstract
We report an isothermal flow calorimeter for characterization of reaction enthalpy and kinetics. The platform consists of a thermoelectric element and a glass–silicon microreactor to measure heat flux and an inline IR spectrometer to monitor reaction conversion. The thermally insulated assembly is calibrated with a thin film heater placed between the microreactor and the thermoelectric element. Without any reconfiguration of hardware, the setup can also be used to efficiently characterize reaction kinetics in transient flow experiments. We tested the calorimeter with hydrolysis of acetic anhydride as a model reaction. We determined the exothermic reaction enthalpy and the endothermic heat of mixing of the reagent to be −63 ± 3.0 kJ mol⁻¹ and +8.8 ± 2.1 kJ mol⁻¹ respectively, in good agreement with literature values and theoretical predictions. Following calorimetry studies, we investigated reaction kinetics by applying carefully controlled residence time ramps at four different temperatures, and we obtained kinetic rate constants of 0.129 min⁻¹ up to 0.522 min⁻¹ for temperatures between 20 °C and 56.3 °C, also fitting well with data reported in the literature.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution 3.0 unported license
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DOI of Published Version
https://doi.org/10.1039/D0RE00304B
