Controllable vapor microbubbles for use in bioparticle actuation
Name
53371738-MIT.pdf
Description
Full printable version
Size
15.88 MB
Format
Adobe PDF
Checksum (MD5)
ae116c2ebba0ddd6b8f13a4b61f7555c
Author(s)
Maxwell, Rebecca Braff, 1974-
Advisor(s)
Martin A. Schmidt, Mehmet Toner and Martha Gray.
Date Issued
2003
Publisher
Massachusetts Institute of Technology
Abstract
In this thesis, we present guidelines for using thermally formed microbubbles as a means of fluidic actuation. The use of microbubbles is attractive due to the simple fabrication and operation of such devices, however, prior work in this area was hindered by several issues inherent to vapor bubble formation that severely limited the reliability of bubble-based devices. It has been shown in this thesis that it is possible to control the location at which bubbles form and the size of the bubbles, as well as to achieve repeatable and reduced bubble formation temperature, and to create bubbles that collapse completely in less than 10 seconds. The achievement of controllable microbubbles makes possible many microfluidic applications, one of which we will demonstrate in this work. We have built a device that is capable of capturing, holding, and selectively releasing single bioparticles using microbubble actuation. This bioparticle actuator could be scaled into an array for the analysis of a large population of individual cells.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2003.
Includes bibliographical references (p. 129-132).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
Persistent DSpace Link
