Surprises From the Basal Ganglia: Stop and Go Have New Meaning
Name
Movement Disorders - 2025 - Graybiel - Surprises From the Basal Ganglia Stop and Go Have New Meaning.pdf
Description
Published version
Size
1.03 MB
Format
Adobe PDF
Checksum (MD5)
ee48161dc21638d660b741123402ba67
Author(s)
Graybiel, Ann M
Date Issued
August 14, 2025
Journal
Movement Disorders
Publisher
Wiley
Citation
Graybiel, A.M. (2025), Surprises From the Basal Ganglia: Stop and Go Have New Meaning. Mov Disord, 40: 2077-2082.
Version
Final published version
Abstract
This perspective highlights new worksuggesting the need for revision of the canonical direct–indirect model of the basal ganglia’s influence on move-ment, with fresh evidence that there is a formerlyunappreciated pair of direct and indirect pathways thatparallel the standard model’s canonical direct and indi-rect pathways, and promising evidence pointing towardimproved clinical treatments for Parkinson’s disease. Asa working hypothesis, it is suggested that the non-canonical direct and indirect pathways, which arise instriosomes, might act as homeostatic circuits that canreign in or amplify the activity of the canonical pathwaysin the face of their imbalance, including that occurring inhyperkinetic or hypokinetic disorders.
MIT Department
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/mds.70008
