A team effort: natural killer cells on the first leg of the tumor immunity relay race
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Author(s)
Fessenden, Timothy B
Duong, Ellen
Spranger-Zimmermann, Stefani
Date Issued
July 2018
Journal
Journal for ImmunoTherapy of Cancer
Publisher
Biomed Central Ltd.
Citation
Fessenden, Timothy B., et al. “A Team Effort: Natural Killer Cells on the First Leg of the Tumor Immunity Relay Race.” Journal for ImmunoTherapy of Cancer, vol. 6, no. 1, Dec. 2018. © 2018 The Author(s)
Version
Final published version
Abstract
Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/s40425-018-0380-4
