Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
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Langer_Synthesis and.pdf
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Author(s)
Gianella, Anita
Mieszawska, Aneta J.
Hoeben, Freek J. M.
Janssen, Henk M.
Jarzyna, Peter A.
Cormode, David P.
Costa, Kevin D.
Rao, Satish
Farokhzad, Omid C.
Langer, Robert
Date Issued
July 2013
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Gianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49, no. 82 (2013): 9392.
Version
Author's final manuscript
Abstract
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
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DOI of Published Version
https://doi.org/10.1039/c3cc43618g
