Modulating Cardiac Hemodynamics Using Tunable Soft Robotic Sleeves in a Porcine Model of HFpEF Physiology for Device Testing Applications (Adv. Funct. Mater. 8/2024)
Name
Adv Funct Materials - 2023 - Rosalia - Modulating Cardiac Hemodynamics Using Tunable Soft Robotic Sleeves in a Porcine.pdf
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5.44 MB
Format
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Checksum (MD5)
7490ade4a579b45297e40cf4ac3a4da1
Author(s)
Rosalia, Luca
Ozturk, Caglar
Wang, Sophie X.
Quevedo‐Moreno, Diego
Saeed, Mossab Y.
Mauskapf, Adam
Roche, Ellen T.
Date Issued
February 2024
Journal
Advanced Functional Materials
Publisher
Wiley
Citation
L. Rosalia, C. Ozturk, S. X. Wang, D. Quevedo-Moreno, M. Y. Saeed, A. Mauskapf, E. T. Roche, Modulating Cardiac Hemodynamics Using Tunable Soft Robotic Sleeves in a Porcine Model of HFpEF Physiology for Device Testing Applications. Adv. Funct. Mater. 2024, 34, 2310085.
Version
Final published version
Abstract
Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular medicine, accounting for ≈50% of all cases of heart failure. Despite the ongoing efforts, no medical device has yet received FDA approval. This is largely due to the lack of an in vivo model of the HFpEF hemodynamics, resulting in the inability to evaluate device effectiveness in vivo prior to clinical trials. Here, the development of a highly tunable porcine model of HFpEF hemodynamics is described using implantable soft robotic sleeves, where controlled actuation of a left ventricular and an aortic sleeve can recapitulate changes in ventricular compliance and afterload associated with a broad spectrum of HFpEF hemodynamic phenotypes. The feasibility of the proposed model in preclinical testing is demonstrated by evaluating the hemodynamic response of the model post-implantation of an interatrial shunt device, which is found to be consistent with findings from in silico studies and clinical trials. This work overcomes limitations of prior HFpEF models, such as low hemodynamic accuracy, high costs, and long development phases. The versatile and adjustable platform introduced can transform HFpEF device development, aiming to enhance the lives of the 32 million people affected globally.
Subjects
Electrochemistry
Condensed Matter Physics
Biomaterials
Electronic, Optical and Magnetic Materials
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1002/adfm.202470045
