Unraveling Tumor Suppressor Networks with In Vivo RNAi
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Hemann_Unraveling tumor.pdf
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Author(s)
Braun, Christian Joerg
Hemann, Michael
Date Issued
June 2013
Journal
Cell Stem Cell
Publisher
Elsevier
Citation
Braun, Christian J., and Michael T. Hemann. “Unraveling Tumor Suppressor Networks with In Vivo RNAi.” Cell Stem Cell 12, no. 6 (June 2013): 639–641. © 2013 Elsevier Inc.
Version
Final published version
Abstract
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.stem.2013.05.020
