Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Name
nihms943926.pdf
Description
Accepted version
Size
629.11 KB
Format
Adobe PDF
Checksum (MD5)
3a0b1cab8263218755417b393dad921e
Author(s)
Song, H-H Greco
Rumma, Rowza T.
Edelman, Elazer R
Date Issued
March 2018
Journal
Cell stem cell
Publisher
Elsevier BV
Citation
Song, H-H Greco et al. “Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.” Cell stem cell, vol. 22, no. 3, 2018, pp. 340-354 © 2018 The Author(s)
Version
Author's final manuscript
Abstract
Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. We also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology. Song et al. explore recent bioengineering advances in creating functional blood macro- and microvessels, particularly featuring stem cells as a seed source. They highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.STEM.2018.02.009
