Bacterial Chromosome Organization and Segregation
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nihms749011.pdf
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1.19 MB
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Adobe PDF
Checksum (MD5)
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Author(s)
Badrinarayanan, Anjana
Le, Tung
Laub, Michael T
Date Issued
November 2015
Journal
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Citation
Badrinarayanan, Anjana et al. “Bacterial Chromosome Organization and Segregation.” Annual Review of Cell and Developmental Biology 31, 1 (November 2015): 171–199 © 2015 by Annual Reviews
Version
Author's final manuscript
Abstract
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances, has begun to reveal the general principles of chromosome organization in bacteria. Here, drawing on studies of many different organisms, we review the emerging picture of how bacterial chromosomes are structured at multiple length scales, highlighting the functions of various DNA-binding proteins and the impact of physical forces. Additionally, we discuss the spatial dynamics of chromosomes, particularly during their segregation to daughter cells. Although there has been tremendous progress, we also highlight gaps that remain in understanding chromosome organization and segregation.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1146/ANNUREV-CELLBIO-100814-125211
