Mechanistic modeling of viral particle production
Name
Biotech Bioengineering - 2022 - Canova - Mechanistic modeling of viral particle production.pdf
Description
Published version
Size
2.41 MB
Format
Adobe PDF
Checksum (MD5)
ce47d6d34594a537a1245961249a23d1
Author(s)
Canova, Christopher T
Inguva, Pavan K
Braatz, Richard D
Date Issued
December 3, 2022
Journal
Biotechnology and Bioengineering
Publisher
Wiley
Citation
Canova, Christopher T, Inguva, Pavan K and Braatz, Richard D. 2022. "Mechanistic modeling of viral particle production." Biotechnology and Bioengineering.
Version
Final published version
Abstract
Viral systems such as wild-type viruses, viral vectors, and virus-like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial-scale production of viral systems remains highly inefficient for multiple reasons. Computational strategies are a promising avenue for improving process development, optimization, and control, but require a mathematical description of the system. This article reviews mechanistic modeling strategies for the production of viral particles, both at the cellular and bioreactor scales. In many cases, techniques and models from adjacent fields such as epidemiology and wild-type viral infection kinetics can be adapted to construct a suitable process model. These process models can then be employed for various purposes such as in-silico testing of novel process operating strategies and/or advanced process control.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/bit.28296
