Pulsation and stabilization: Contractile forces that underlie morphogenesis
Name
Martin Dev Bio.pdf
Description
main article
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3.08 MB
Format
Adobe PDF
Checksum (MD5)
69f8e9b3d2028cf4250d39745330dd0c
Author(s)
Martin, Adam C
Date Issued
May 2010
Journal
Developmental Biology
Publisher
Elsevier B.V.
Citation
Martin, Adam C. “Pulsation and stabilization: Contractile forces that underlie morphogenesis.” Developmental Biology 341 (2010): 114-125.
Version
Author's final manuscript
Abstract
Embryonic development involves global changes in tissue shape and architecture that are driven by cell shape changes and rearrangements within cohesive cell sheets. Morphogenetic changes at the cell and tissue level require that cells generate forces and that these forces are transmitted between the cells of a coherent tissue. Contractile forces generated by the actin–myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Recent studies that have combined live imaging with computational and biophysical approaches have provided new insights into how contractile forces are generated and coordinated between cells and tissues. In this review, we discuss our current understanding of the mechanical forces that shape cells, tissues, and embryos, emphasizing the different modes of actomyosin contraction that generate various temporal and spatial patterns of force generation.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.ydbio.2009.10.031
