Biomechanics of the human chorioamnion
Name
76906810-MIT.pdf
Description
Full printable version
Size
4.28 MB
Format
Adobe PDF
Checksum (MD5)
5d71a440a245a7dd6d0ac09bb26ae923
Author(s)
Prévost, Thibault Philippe
Advisor(s)
Subra Suresh and Simona Socrate.
Date Issued
2006
Publisher
Massachusetts Institute of Technology
Abstract
The human fetal membrane, namely the chorioamnion, is the structural soft tissue retaining the amniotic fluid and the fetus during pregnancy. Its biomechanical integrity is crucial for maintaining a healthy gestation and a successful delivery. The premature rupture of the fetal membrane (PROM) can result in serious perinatal complications. Despite extensive research in this field, the mechanical and biochemical processes governing the membrane deformation and failure remain poorly understood. The aim of this study is to characterize the mechanical behavior of the chorioamnionic tissue along with its biochemical properties, through mechanical testing and biochemical analyses. In order to accomplish this goal, specific mechanical and biochemical testing protocols were developed. In vitro mechanical testing was performed on samples from seven patients under different uniaxial and biaxial loading conditions. Significant relaxation was noted under uniaxial loading while very limited creep was observed under biaxial loading. Biochemical measurements such as collagen and sulfated glycosaminoglycan contents were also obtained. In addition, a microstructurally based constitutive model for the fetal membrane is proposed.
(cont.) The model allows for nonlinear hyperelastic response at large deformation. We also propose a framework to capture the time-dependent response of the tissue. The model was implemented in a finite element formulation to allow three-dimensional simulations of membrane deformation.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.
Includes bibliographical references (leaves 108-115).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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