Mitigation of sickle cell crises using chaos-based analysis
Name
1036984727-MIT.pdf
Description
Full printable version
Size
3.36 MB
Format
Adobe PDF
Checksum (MD5)
02bdae284c1afcbbdfa7f0d47d858e05
Author(s)
Atsaves, Louis
Advisor(s)
Wesley Harris.
Date Issued
2018
Publisher
Massachusetts Institute of Technology
Abstract
Sickle-cell diseased persons suffer finite pain episodes (luring their lifetime, which are termed sickle cell crises. Using a sickle cell blood flow model, we mathematically demonstrate that the onset of a sickle cell crisis is chaotic. We further show that sickle cell crises may be mitigated by manipulating certain physiological parameters, namely the partial pressure of oxygen at 50% hemoglobin ([mathematical formula]%) and the kinetic dissociation rate of hemoglobin (kub) These physiological parameters control the chaotic nature of sickle cell crises and have the ability to transfer a person from a crisis state to a non-crisis state. We determine that sickle cell crises may only be mitigated within a critical time period (0
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Aeronautics and Astronautics, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (page 39).
Subjects
Aeronautics and Astronautics.
MIT Department
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
Terms of Use
MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.
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