Antibody-modified conduits for extracorporeal selective cytokine filtration in sepsis
Name
964450893-MIT.pdf
Description
Full printable version
Size
3.25 MB
Format
Adobe PDF
Checksum (MD5)
82adb96a0407b0d34d1c6a4b32d94bd2
Author(s)
Moroi, Morgan K
Advisor(s)
Robert S. Langer.
Alternative Title
AMCs for extracorporeal selective cytokine filtration in sepsis
Date Issued
2016
Publisher
Massachusetts Institute of Technology
Abstract
Sepsis kills millions of people worldwide each year and occurs when microorganisms enter the bloodstream of an infected host. The presence of microorganisms in the bloodstream triggers the body to produce many inflammatory proteins, known as cytokines, that cause damage to blood vessels and vital organs. This leads to capillary leak, failing organs, and often death. We have developed a novel approach to modulate the inflammatory response, using antibody-modified conduits (AMCs) to filter harmful cytokines selectively from the circulation and in a time-specific manner. Here, we characterize variables that affect AMC performance to determine optimal AMC conditions for later use downstream.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2016.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 37-39).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
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