Skin permeabilization for transdermal drug delivery: recent advances and future prospects
Name
Blankschtein_Skin permeabilization.pdf
Size
1.42 MB
Format
Adobe PDF
Checksum (MD5)
4db506107cc12a7c2553b8a91fb0ac35
Author(s)
Schoellhammer, Carl Magnus
Blankschtein, Daniel
Langer, Robert
Date Issued
March 2014
Journal
Expert Opinion on Drug Delivery
Publisher
Informa UK (Informa Healthcare)
Citation
Schoellhammer, Carl M, Daniel Blankschtein, and Robert Langer. “Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects.” Expert Opin. Drug Deliv. 11, no. 3 (March 2014): 393–407.
Version
Author's final manuscript
Abstract
Introduction: Transdermal delivery has potential advantages over other routes of administration. It could reduce first-pass metabolism associated with oral delivery and is less painful than injections. However, the outermost layer of the skin, the stratum corneum (SC), limits passive diffusion to small lipophilic molecules. Therefore, methods are needed to safely permeabilize the SC so that ionic and larger molecules may be delivered transdermally.
Areas covered: This review focuses on low-frequency sonophoresis, microneedles, electroporation and iontophoresis, and combinations of these methods to permeabilize the SC. The mechanisms of enhancements and developments in the last 5 years are discussed. Potentially high-impact applications, including protein delivery, vaccination and sensing are presented. Finally, commercial interest and clinical trials are discussed.
Expert opinion: Not all permeabilization methods are appropriate for all applications. Focused studies into applications utilizing the advantages of each method are needed. The total dose and kinetics of delivery must be considered. Vaccination is one application where permeabilization methods could make an impact. Protein delivery and analyte sensing are also areas of potential impact, although the amount of material that can be delivered (or extracted) is of critical importance. Additional work on the miniaturization of these technologies will help to increase commercial interest.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1517/17425247.2014.875528
