Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation
Name
Berrios-2016-Merkel Cell Polyomavirus Small T.pdf
Size
2.38 MB
Format
Adobe PDF
Checksum (MD5)
58dd27d880ad5618810ce3a38bc40e92
Author(s)
Berrios, Christian
Padi, Megha
Park, Donglim Esther
Molla, Vadim
Cheng, Jingwei
Lee, Soo Mi
Stephanopoulos, Gregory
Quackenbush, John
DeCaprio, James A.
Keibler, Mark Andrew
Date Issued
November 2016
Journal
PLOS Pathogens
Publisher
Public Library of Science
Citation
Berrios, Christian et al. “Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.” Ed. Robert F. Kalejta. PLOS Pathogens 12.11 (2016): e1006020.
Version
Final published version
Abstract
An accurate analytic model describing the microscopic mechanism of high-harmonic generation (HHG) in solids is derived. Extensive first-principles simulations within a time-dependent density-functional framework corroborate the conclusions of the model. Our results reveal that (i) the emitted HHG spectra are highly anisotropic and laser-polarization dependent even for cubic crystals; (ii) the harmonic emission is enhanced by the inhomogeneity of the electron-nuclei potential; the yield is increased for heavier atoms; and (iii) the cutoff photon energy is driver-wavelength independent. Moreover, we show that it is possible to predict the laser polarization for optimal HHG in bulk crystals solely from the knowledge of their electronic band structure. Our results pave the way to better control and optimize HHG in solids by engineering their band structure.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1371/journal.ppat.1006020
