TGF-β signaling in cellular senescence and aging-related pathology
Name
ijms-20-05002-v2.pdf
Size
1.16 MB
Format
Adobe PDF
Checksum (MD5)
44d9ac9b108eb50dd5a7254f201f8cb6
Author(s)
Tominaga, Kana
Suzuki, Hiroshi I.
Date Issued
October 10, 2019
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Citation
Tominaga, Kana, and Hiroshi I. Suzuki, "TGF-β signaling in cellular senescence and aging-related pathology." International Journal of Molecular Sciences 20 (2019): no. 5002 doi 10.3390/ijms20205002 ©2019 Author(s)
Version
Final published version
Abstract
Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and thought to contribute to the aging pathologies. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that regulates a myriad of cellular processes and has important roles in embryonic development, physiological tissue homeostasis, and various pathological conditions. TGF-β exerts potent growth inhibitory activities in various cell types, and multiple growth regulatory mechanisms have reportedly been linked to the phenotypes of cellular senescence and stem cell aging in previous studies. In addition, accumulated evidence has indicated a multifaceted association between TGF-β signaling and aging-associated disorders, including Alzheimer’s disease, muscle atrophy, and obesity. The findings regarding these diseases suggest that the impairment of TGF-β signaling in certain cell types and the upregulation of TGF-β ligands contribute to cell degeneration, tissue fibrosis, inflammation, decreased regeneration capacity, and metabolic malfunction. While the biological roles of TGF-β depend highly on cell types and cellular contexts, aging-associated changes are an important additional context which warrants further investigation to better understand the involvement in various diseases and develop therapeutic options. The present review summarizes the relationships between TGF-β signaling and cellular senescence, stem cell aging, and aging-related diseases. ©2019 keywords: transforming growth factor-β (TGF-β); cellular senescence; stem cell; aging
Subjects
Physical and Theoretical Chemistry
Inorganic Chemistry
Organic Chemistry
Spectroscopy
Molecular Biology
Catalysis
General Medicine
Computer Science Applications
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/ijms20205002
