Controlling timing and location in vaccines
Name
1-s2.0-S0169409X2030065X-main.pdf
Description
Published version
Size
3.88 MB
Format
Adobe PDF
Checksum (MD5)
0b215d1dc0c0ef372ba29176ab7b6c3d
Author(s)
Irvine, Darrell J
Aung, Aereas
Silva, Murillo
Date Issued
June 2020
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Citation
Irvine, Darrell J. et al. "Controlling timing and location in vaccines." Forthcoming in Advanced Drug Delivery Reviews (June 2020): http://dx.doi.org/10.1016/j.addr.2020.06.019 © 2020 The Authors
Version
Final published version
Abstract
Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence of antigen and inflammatory cues for an appropriate temporal duration within the lymph nodes, and further within appropriate subcompartments of the lymph nodes– the right timing and location– play a critical role in shaping cellular and humoral immunity. Here we review recent advances in our understanding of how vaccine kinetics and biodistribution impact adaptive immunity, and the underlying immunological mechanisms that govern these responses. We discuss emerging approaches to engineer these properties for future vaccines, with a focus on subunit vaccines.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.addr.2020.06.019
