Polymer synthesis for corona phase molecular recognition based on single-walled carbon nanotubes
Name
1057894392-MIT.pdf
Description
Full printable version
Size
4.69 MB
Format
Adobe PDF
Checksum (MD5)
fd2a05329b30dee410eeecbf3e25722d
Author(s)
Sun, Jessica H
Advisor(s)
Michael S. Strano.
Date Issued
2018
Publisher
Massachusetts Institute of Technology
Abstract
Current work within Strano Research Group shows that single-walled carbon nanotubes (SWNT) wrapped with methacrylic acid-styrene heteropolymer (MA-ST) can be used for specific corona phase molecular recognition (CoPhMoRe) of Vardenafil, a small molecule drug. This project is a follow-up study on viability of related polymers for CoPhMoRe sensing of five small molecule drugs: Fluticasone, Sumatriptan, Valacyclovir, Vardenafil, and Bupropion. Methacrylic acid-vinylphenylboronic acid (MA-VBA) heteropolymer and acrylic acid-styrene (AA-ST) heteropolymer were synthesized at different monomer ratios and chain lengths. These polymers were suspended with the carbon nanotubes and screened against the five drugs. The (12,1) chirality of MA-VBA-4 and (7,5) chirality of AA-ST-2 were found to be potential candidates for sensing of Fluticasone and Vardenafil respectively. However, MA-ST 8 remains as the superior choice for the specific sensing of Vardenafil.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 32-34).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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