Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding
Author(s)
Duclos Yevick, Hannah Gabrielle
Miller, Pearson Whitehead
Dunkel, Joern
Martin, Adam C
Date Issued
September 2019
Journal
Developmental Cell
Publisher
Elsevier BV
Citation
Yevick, Hannah G. et al. "Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding." Developmental Cell 50, 5 (September 2019): P586-598.e3 © 2019 Elsevier Inc
Version
Author's final manuscript
Abstract
Tissue morphogenesis is strikingly robust. Yet, how tissues are sculpted under challenging conditions is unknown. Here, we combined network analysis, experimental perturbations, and computational modeling to determine how network connectivity between hundreds of contractile cells on the ventral side of the Drosophila embryo ensures robust tissue folding. We identified two network properties that mechanically promote robustness. First, redundant supracellular cytoskeletal network paths ensure global connectivity, even with network degradation. By forming many more connections than are required, morphogenesis is not disrupted by local network damage, analogous to the way redundancy guarantees the large-scale function of vasculature and transportation networks. Second, directional stiffening of edges oriented orthogonal to the folding axis promotes furrow formation at lower contractility levels. Structural redundancy and directional network stiffening ensure robust tissue folding with proper orientation.
MIT Department
Massachusetts Institute of Technology. Department of Physics
Massachusetts Institute of Technology. Department of Mathematics
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.devcel.2019.06.015
