Anatomical connectivity patterns predict face selectivity in the fusiform gyrus
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Gabrieli_Anatomical connectivity.pdf
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Author(s)
Koldewyn, Kami
Reynolds, Gretchen
Saygin, Zeynep M.
Osher, David E.
Gabrieli, John D. E.
Saxe, Rebecca R.
Date Issued
December 2011
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Saygin, Zeynep M, David E Osher, Kami Koldewyn, Gretchen Reynolds, John D E Gabrieli, and Rebecca R Saxe. “Anatomical Connectivity Patterns Predict Face Selectivity in the Fusiform Gyrus.” Nat Neurosci 15, no. 2 (December 25, 2011): 321–327.
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Author's final manuscript
Abstract
A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural connectivity, as measured through diffusion-weighted imaging, we were able to predict functional activation to faces in the fusiform gyrus. These predictions outperformed two control models and a standard group-average benchmark. The structure–function relationship discovered from the initial participants was highly robust in predicting activation in a second group of participants, despite differences in acquisition parameters and stimuli. This approach can thus reliably estimate activation in participants who cannot perform functional imaging tasks and is an alternative to group-activation maps. Additionally, we identified cortical regions whose connectivity was highly influential in predicting face selectivity within the fusiform, suggesting a possible mechanistic architecture underlying face processing in humans.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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DOI of Published Version
https://doi.org/10.1038/nn.3001
