Targeted Synthesis of 3,3′-, 3,4′- and 3,6′-Phenylpropanoid Sucrose Esters
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Author(s)
Kathy, Wong Pooi Wen
Ong, Li Lin
Devaraj, Surabhi
Khong, Duc Thinh
Judeh, Zaher M. A.
Date Issued
January 2022
Journal
Molecules
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Molecules 27 (2): 535 (2022)
Version
Final published version
Abstract
In this study, we report on an orthogonal strategy for the precise synthesis of 3,3′-, 3,4′-, and 3,6′-phenylpropanoid sucrose esters (PSEs). The strategy relies on carefully selected protecting groups and deprotecting agents, taking into consideration the reactivity of the four free hydroxyl groups of the key starting material: di-isopropylidene sucrose 2. The synthetic strategy is general, and potentially applies to the preparation of many natural and unnatural PSEs, especially those substituted at 3-, 3′-, 4′- and 6′-positions of PSEs.
MIT Department
Singapore-MIT Alliance in Research and Technology (SMART)
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/molecules27020535
