Strain Release in Organic Photonic Nanoparticles for Protease Sensing
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2.88 MB
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128e7785245ac69d6050d4a0da5f656d
Author(s)
Cordovilla, Carlos
Swager, Timothy Manning
Date Issued
April 2012
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Citation
Cordovilla, Carlos, and Timothy M. Swager. “Strain Release in Organic Photonic Nanoparticles for Protease Sensing.” Journal of the American Chemical Society 134.16 (2012): 6932–6935. CrossRef. Web.
Version
Author's final manuscript
Abstract
Proteases are overexpressed in most cancers and proteolytic activity has been shown to be a viable marker for cancer imaging in vivo. Herein, we describe the synthesis of luminescence-quenched shell cross-linked nanoparticles as photonic nanoprobes for protease sensing. Protease sensing scheme is based on a “turn-on” mechanism where the protease cleaves peptide cross-linkers of the fluorescence-quenched shell cross-linked NP (OFF state) leading to a highly emissive non-cross linked NP (ON state). The cross-linked particles can be strained by exposure to a good solvent and proteolysis allows for particle expansion (swelling) and a recovery of the luminescence.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja301259v
