The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
Name
57351067-MIT.pdf
Description
Full printable version
Size
2.45 MB
Format
Adobe PDF
Checksum (MD5)
72f0ffbaecc5d9884ca2c2e4409b29d9
Author(s)
Lai, Leslie, 1981-
Advisor(s)
Leona D. Samson and Peter C. Dedon.
Date Issued
2004
Publisher
Massachusetts Institute of Technology
Abstract
Recent epidemiological data has indicated that chronic exposure to metals such as arsenic and cadmium increases the risk of cancer and other diseases. These metals may have negative biological effects on cells by disrupting homeostatic cellular processes and altering normal signal transduction. One possible mechanism for many of these negative effects may involve overproduction of reactive oxygen species that damage proteins, lipids, carbohydrates, and nucleic acids. To compound this oxidative damage, there is evidence consistent with the inhibition of repair of damaged DNA by these metals. As a result, there is an increase in mutagenicity and toxicity in the organisms. This thesis reviews the current literature relevant to the biochemistry and biology of arsenic and cadmium.
Description
Thesis (S.M. in Molecular Systems Toxicology)--Massachusetts Institute of Technology, Biological Engineering Division, 2004.
Includes bibliographical references (leaves 38-43).
Subjects
Biological Engineering Division.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
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