Diffusion MR tractography of the heart
Name
Sosnovik-2009-Diffusion MR tractog.pdf
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8.42 MB
Format
Adobe PDF
Checksum (MD5)
379c429e52fdeb76abe714196ebc889c
Author(s)
Wedeen, Van J.
Sosnovik, David
Reese, Timothy G.
Dai, Guangping
Wang, Ruopeng
Date Issued
November 2009
Journal
Journal of Cardiovascular Magnetic Resonance
Publisher
BioMed Central
Citation
Sosnovik, David et al. “Diffusion MR tractography of the heart.” Journal of Cardiovascular Magnetic Resonance 11.1 (2009): 47.
Version
Final published version
Abstract
Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging technique known as diffusion spectrum imaging or DSI. The properties of DSI make it particularly suited to the generation of 3-dimensional tractograms of myofiber architecture. In this article we review the physical basis of diffusion-tractography in the myocardium and the attributes of the available techniques, placing particular emphasis on DSI. The application of DSI in ischemic heart disease is reviewed, and the requisites for widespread clinical translation of diffusion MR tractography in the heart are discussed.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution
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DOI of Published Version
http://dx.doi.org/10.1186/1532-429x-11-47
