Rapid experience-dependent plasticity of synapse function and structure in ferret visual cortex in vivo
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Yu-2011-Rapid experience-dep.pdf
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Author(s)
Yu, Hongbo
Majewska, Ania K.
Sur, Mriganka
Date Issued
December 2011
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences of the United States of America
Citation
Yu, H., A. K. Majewska, and M. Sur. “Rapid Experience-dependent Plasticity of Synapse Function and Structure in Ferret Visual Cortex in Vivo.” Proceedings of the National Academy of Sciences 108.52 (2011): 21235–21240. Copyright ©2011 by the National Academy of Sciences
Version
Final published version
Abstract
The rules by which visual experience influences neuronal responses and structure in the developing brain are not well understood. To elucidate the relationship between rapid functional changes and dendritic spine remodeling in vivo, we carried out chronic imaging experiments that tracked visual responses and dendritic spines in the ferret visual cortex following brief periods of monocular deprivation. Functional changes, which were largely driven by loss of deprived eye responses, were tightly regulated with structural changes at the level of dendritic spines, and occurred very rapidly (on a timescale of hours). The magnitude of functional changes was correlated with the magnitude of structural changes across the cortex, and both these features reversed when the deprived eye was reopened. A global rule governed how the responses to the two eyes or changes in spines were altered by monocular deprivation: the changes occurred irrespective of regional ocular dominance preference and were independently mediated by each eye, and the loss or gain of responses/spines occurred as a constant proportion of predeprivation drive by the deprived or nondeprived eye, respectively.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1108270109
