3-Dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits
Name
Boyden_Three-dimensional multiwaveguide.pdf
Size
1.67 MB
Format
Adobe PDF
Checksum (MD5)
56ebfd10b4f8db059a51485335eaa8b3
Author(s)
Zorzos, Anthony Nicholas
Scholvin, Jorg
Fonstad, Clifton G., Jr.
Boyden, Edward
Alternative Title
Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits
Date Issued
November 2012
Journal
Optics Letters
Publisher
Optical Society of America
Citation
Zorzos, Anthony N. et al. “Three-dimensional Multiwaveguide Probe Array for Light Delivery to Distributed Brain Circuits.” Optics Letters 37.23 (2012): 4841.
Version
Author's final manuscript
Abstract
To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are commonly used. However, an optical fiber is limited to delivering light to a single target within the 3D structure of the brain. Here, we describe the design and fabrication of an array of thin microwaveguides, which terminates at a three-dimensionally distributed set of points, appropriate for delivering light to targets distributed in a 3D pattern throughout the brain.
Description
2013 February 14, Author Manuscript
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Media Laboratory
Massachusetts Institute of Technology. Microsystems Technology Laboratories
McGovern Institute for Brain Research at MIT
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1364/OL.37.004841
