Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer
Name
nihms-977830.pdf
Description
Accepted version
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2.96 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Xie, Xi
Doloff, Joshua C
Yesilyurt, Volkan
Sadraei, Atieh
McGarrigle, James J.
Omami, Mustafa
Veiseh, Omid
Farah, Shady
Isa, Douglas
Ghani, Sofia
Date Issued
July 30, 2018
Publisher
Springer Science and Business Media LLC
Citation
Xie, Xi, Doloff, Joshua C, Yesilyurt, Volkan, Sadraei, Atieh, McGarrigle, James J. et al. 2018. "Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer." 2 (12).
Version
Author's final manuscript
Abstract
© 2018, Nature Publishing Group. All rights reserved. Continuous glucose monitors (CGMs), used by patients with diabetes mellitus, can autonomously track fluctuations in blood glucose over time. However, the signal produced by CGMs during the initial recording period following sensor implantation contains substantial noise, requiring frequent recalibration via finger-prick tests. Here, we show that coating the sensor with a zwitterionic polymer, found via a combinatorial chemistry approach, significantly reduces signal noise and improves CGM performance. We evaluated the polymer-coated sensors in mice as well as in healthy and diabetic non-human primates, and show that the sensors accurately record glucose levels without the need for recalibration. We also show that the coated sensors significantly abrogated immune responses, as indicated by histology, fluorescent whole-body imaging of inflammation-associated protease activity and gene expression of inflammation markers. The polymer coating may allow CGMs to become standalone measuring devices.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/s41551-018-0273-3
