Ultrasound-triggered local anaesthesia
Name
nihms888855.pdf
Description
Accepted version
Size
1.93 MB
Format
Adobe PDF
Checksum (MD5)
d45bb3e209ed2a2b24029d9ab3a98853
Author(s)
Rwei, Alina Y
Paris, Juan L.
Wang, Bruce
Wang, Weiping
Axon, Christopher D.
Vallet-Regí, María
Langer, Robert S
Kohane, Daniel S.
Date Issued
August 2017
Journal
Nature Biomedical Engineering
Publisher
Springer Nature America, Inc
Citation
Rwei, Alina Y. et al., "Ultrasound-triggered local anaesthesia." Nature Biomedical Engineering 1, 8 (August 2017): 644–53 ©2017 Authors
Version
Author's final manuscript
Abstract
On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve blocks in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve blocks to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produced reactive oxygen species that reacted with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin. Repeatable ultrasound-triggered nerve blocks were achieved in vivo, with the nerve-block duration depending on the extent and intensity of insonation. There was no detectable systemic toxicity and tissue reaction was benign in all groups. On-demand, personalized local anaesthesia could be beneficial for the management of relatively localized pain states and could potentially minimize opioid use. ©2017 The Author(s).
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/S41551-017-0117-6
