Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model
Name
nihms-1037395.pdf
Description
Accepted version
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1.92 MB
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Checksum (MD5)
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Author(s)
El‐Kurdi, Mohammed
Soletti, Lorenzo
McGrath, Jonathan
Linhares, Stephen
Rousselle, Serge
Greisler, Howard
Edelman, Elazer R
Schoen, Frederick J
Date Issued
2019
Journal
Journal of Biomedical Materials Research - Part A
Publisher
Wiley
Version
Author's final manuscript
Abstract
© 2019 Wiley Periodicals, Inc. Saphenous vein graft (SVG) failure rates are unacceptably high, and external mechanical support may improve patency. We studied the histologic remodeling of a conformal, electrospun, polydimethylsiloxane-based polyether urethane external support device for SVGs and evaluated graft structural evolution in adult sheep to 2 years. All sheep (N = 19) survived to their intended timepoints, and angiography showed device-treated SVG geometric stability over time (30, 90, 180, 365, or 730 days), with an aggregated graft patency rate of 92%. There was minimal inflammation associated with the device material at all timepoints. By 180 days, treated SVG remodeling was characterized by minimal/nonprogressive intimal hyperplasia; polymer fragmentation and integration; as well as the development of a neointima, and a confluent endothelium. By 1-year, the graft developed a media-like layer by remodeling the neointima, and elastic fibers formed well-defined structures that subtended the neo-medial layer of the remodeled SVG. Immunohistochemistry showed that this neo-media was populated with smooth muscle cells, and the intima was lined with endothelial cells. These data suggest that treated SVGs were structurally remodeled by 180 days, and developed arterial-like features by 1 year, which continued to mature to 2 years. Device-treated SVGs remodeled into arterial-like conduits with stable long-term performance as arterial grafts in adult sheep.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/JBM.A.36724
