Cortical information flow during flexible sensorimotor decisions
Name
Miller_Cortical information.pdf
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774.64 KB
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Author(s)
Siegel, Markus
Buschman, Timothy J.
Miller, Earl K.
Date Issued
June 2015
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Siegel, M., T. J. Buschman, and E. K. Miller. “Cortical Information Flow during Flexible Sensorimotor Decisions.” Science 348, no. 6241 (June 19, 2015): 1352–55.
Version
Author's final manuscript
Abstract
During flexible behavior, multiple brain regions encode sensory inputs, the current task, and choices. It remains unclear how these signals evolve. We simultaneously recorded neuronal activity from six cortical regions [middle temporal area (MT), visual area four (V4), inferior temporal cortex (IT), lateral intraparietal area (LIP), prefrontal cortex (PFC), and frontal eye fields (FEF)] of monkeys reporting the color or motion of stimuli. After a transient bottom-up sweep, there was a top-down flow of sustained task information from frontoparietal to visual cortex. Sensory information flowed from visual to parietal and prefrontal cortex. Choice signals developed simultaneously in frontoparietal regions and travelled to FEF and sensory cortex. This suggests that flexible sensorimotor choices emerge in a frontoparietal network from the integration of opposite flows of sensory and task information.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.aab0551
