Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity
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Description
Published version
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3.54 MB
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Checksum (MD5)
c8519394e97dddf0fbc329c7810921d1
Author(s)
Zhivaki, Dania
Borriello, Francesco
Chow, Ohn A
Doran, Benjamin
Fleming, Ira
Theisen, Derek J
Pallis, Paris
Shalek, Alex K
Sokol, Caroline L
Zanoni, Ivan
Date Issued
2020
Journal
Cell Reports
Publisher
Elsevier BV
Citation
Zhivaki, Dania, Borriello, Francesco, Chow, Ohn A, Doran, Benjamin, Fleming, Ira et al. 2020. "Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity." Cell Reports, 33 (7).
Version
Final published version
Abstract
© 2020 The Author(s) Inflammasome activation in dendritic cells (DCs) leads to pyroptosis or hyperactivation. Zhivaki et al. show that in contrast to pyroptotic DCs, hyperactive DCs stimulate durable anti-tumor immunity that eradicates established tumors. These protective responses are intrinsic to cDC1 cells and depend on DC hypermigration and on the inflammasome-dependent cytokine IL-1β.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
Ragon Institute of MGH, MIT and Harvard
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CELREP.2020.108381
