In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory
Name
nihms839046.pdf
Description
Accepted version
Size
601.59 KB
Format
Adobe PDF
Checksum (MD5)
e63e5a61bb57430f39be9319105e3f05
Author(s)
Watson, Lauren Ashley
Tsai, Li-Huei
Date Issued
April 2017
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Watson, L. Ashley et al. "In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory." Current Opinion in Neurobiology 43 (April 2017): 48-55 © 2016 Elsevier Ltd
Version
Author's final manuscript
Abstract
Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organization is emerging as a key factor in dynamic transcriptional regulation of the post-mitotic neuron. For instance, neuronal activity induces relocalization of gene loci to ‘transcription factories’, and specific enhancer–promoter looping contacts allow for precise transcriptional regulation. Moreover, neuronal activity-dependent DNA double-strand break formation in the promoter of immediate early genes appears to overcome topological constraints on transcription. Together, these findings point to a critical role for genome topology in integrating dynamic environmental signals to define precise spatiotemporal gene expression programs supporting cognitive processes.
Subjects
General Neuroscience
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.conb.2016.12.002
