‘Hygienic’ Lymphocytes Convey Increased Cancer Risk
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Alm_Hygenic lymphocytes.pdf
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Author(s)
Levkovich, Tatiana
Poutahidis, Theofilos
Cappelle, Kelsey
Smith, Mark Burnham
Perrotta, Allison Rose
Alm, Eric J.
Erdman, Susan E.
Date Issued
August 2014
Journal
Journal of Analytical Oncology
Publisher
Lifescience Global
Citation
Erdman, Susan, Tatiana Levkovich, Theofilos Poutahidis, Kelsey Cappelle, Mark Smith, Allison Perrotta, and Eric Alm. “‘Hygienic’ Lymphocytes Convey Increased Cancer Risk.” Journal of Analytical Oncology 3, no. 3 (August 12, 2014): 113–121.
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Author's final manuscript
Abstract
Risk of developing inflammation-associated cancers has increased in industrialized countries during the past 30 years. One possible explanation is societal hygiene practices with use of antibiotics and Caesarian births that provide too few early life exposures of beneficial microbes. Building upon a ‘hygiene hypothesis’ model whereby prior microbial exposures lead to beneficial changes in CD4+ lymphocytes, here we use an adoptive cell transfer model and find that too few prior microbe exposures alternatively result in increased inflammation-associated cancer growth in susceptible recipient mice. Specifically, purified CD4+ lymphocytes collected from ‘restricted flora’ donors increases multiplicity and features of malignancy in intestinal polyps of recipient Apc[superscript Min/+] mice, coincident with increased inflammatory cell infiltrates and instability of the intestinal microbiota. We conclude that while a competent immune system serves to maintain intestinal homeostasis and good health, under hygienic rearing conditions CD4+ lymphocytes instead exacerbate inflammation-associated tumorigenesis, subsequently contributing to more frequent cancers in industrialized societies.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
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DOI of Published Version
https://doi.org/10.6000/1927-7229.2014.03.03.1
