Coordination in Brain Systems
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Coordination in Brain Systems.pdf
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Author(s)
Moser, Edvard I.
Corbetta, Maurizio
Desimone, Robert
Fregnac, Yves
Fries, Pascal
Graybiel, Ann M.
Haynes, John-Dylan
Itti, Laurent
Melloni, Lucia
Monyer, Hannah
Date Issued
January 2010
Journal
Fifth Ernst Strungmann Forum on Dynamic Coordination in the Brain: From Neurons to Mind
Publisher
MIT Press
Citation
Moser, Edvard I. et al. "Coordination in Brain Systems." Chapter 13 from "Dynamic Coordination in the Brain: From Neurons to Mind," edited by C. von der Malsburg, W. A. Phillips, and W. Singer. (Strungmann Forum Report, vol. 5.) Cambridge, MA: MIT Press.
Version
Author's final manuscript
Abstract
This chapter reviews the concept of dynamic coordination, its mechanistic implementation
in brain circuits, and the extent to which dynamic coordination, and specific
manifestations of it, have the power to account for functions performed by interacting
brain systems. In our discussions, we addressed how on-the- y changes in coupling
between neural subpopulations might enable the brain to handle the fast-changing recombination of processing elements thought to underlie cognition. Such changes in
coupling should be apparent, rst and foremost, in the statistical relationship between
activity in interconnected brain systems, rather than in the individual ring patterns of
each subsystem. Dynamic coordination may manifest itself through a variety of mechanisms,
of which oscillation-based synchronization is likely to play an important but
not exclusive role. Also discussed is how modulation of phase relationships of oscillations
in different brain systems, in neocortex and hippocampus of the mammalian
brain, may change functional coupling, and how such changes may play a role in routing
of signals at cross sections between cortical areas and hippocampal subdivisions.
Possible mechanisms for oscillation-based synchronization, particularly in the gamma
frequency range, are explored. It is acknowledged that the brain is likely capable of
producing zero-phase lag between spatially dispersed cell populations by way of rather
simple coupling mechanisms, primarily when neuronal groups are coupled symmetrically.
Synchronization with remote areas may be most ef cient with phase differences
that match the conduction delays. Fast-conducting, long-range projecting interneurons
are identi ed as a potential substrate for synchronizing one neural circuit with another.
A number of research strategies are identi ed to enhance our understanding of dynamic
coordination of brain systems and how it might contribute to the implementation of the
functions of those systems.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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http://www.brain.mpg.de/fileadmin/user_upload/Documents/Download/Singer_Emeritus_Group/13GR3__20MOSERV50.PDF
