Etiology of Burst Suppression EEG Patterns
Name
fpsyg-12-673529.pdf
Description
Published version
Size
399.11 KB
Format
Adobe PDF
Checksum (MD5)
8d22c12ecbc20156512e0f4471310dbb
Author(s)
Shanker, Akshay
Abel, John H
Schamberg, Gabriel
Brown, Emery Neal
Date Issued
2021
Journal
Frontiers in Psychology
Publisher
Frontiers Media SA
Version
Final published version
Abstract
Burst-suppression electroencephalography (EEG) patterns of electrical activity, characterized by intermittent high-power broad-spectrum oscillations alternating with isoelectricity, have long been observed in the human brain during general anesthesia, hypothermia, coma and early infantile encephalopathy. Recently, commonalities between conditions associated with burst-suppression patterns have led to new insights into the origin of burst-suppression EEG patterns, their effects on the brain, and their use as a therapeutic tool for protection against deleterious neural states. These insights have been further supported by advances in mechanistic modeling of burst suppression. In this Perspective, we review the origins of burst-suppression patterns and use recent insights to weigh evidence in the controversy regarding the extent to which burst-suppression patterns observed during profound anesthetic-induced brain inactivation are associated with adverse clinical outcomes. Whether the clinical intent is to avoid or maintain the brain in a state producing burst-suppression patterns, monitoring and controlling neural activity presents a technical challenge. We discuss recent advances that enable monitoring and control of burst suppression.
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.3389/fpsyg.2021.673529
https://doi.org/10.3389/fpsyg.2021.673529
