In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration
Name
nihms-1543715.pdf
Description
Accepted version
Size
2.19 MB
Format
Unknown
Checksum (MD5)
6872378f110c4a36118cbb43edc85f88
Author(s)
Sangaré, Lamba Omar
Ólafsson, Einar B.
Wang, Yifan
Yang, Ninghan
Julien, Lindsay
Camejo, Ana
Pesavento, Patricia
Sidik, Saima M.
Lourido, Sebastian
Barragan, Antonio
Date Issued
October 2019
Journal
Cell Host & Microbe
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2019 Elsevier Inc. Sangaré et al. use a CRISPR screen to determine the in vivo fitness of Toxoplasma genes. They identify a secreted protein, TgWIP, which determines dendritic cell motility and transmigration in the infected host. In mice, TgWIP determines T. gondii dissemination from the site of infection to distant organs.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.chom.2019.09.008
