Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions
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jfb-02-00088.pdf
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Author(s)
Dolatshahi-Pirouz, Alireza
Nikkhah, Mehdi
Kolind, Kristian
Dokmeci, Mehmet R.
Khademhosseini, Alireza
Date Issued
June 2011
Journal
Journal of Functional Biomaterials
Publisher
MDPI AG
Citation
Dolatshahi-Pirouz, Alireza et al. "Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions." Journal of Functional Biomaterials 2, 3 (June 2011): 88-106 © 2011 The Author(s)
Version
Final published version
Abstract
As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells. Keywords: micro- and nanotopography; microwells; microarrays; embryonic and adult stem cells; stem cell therapy
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/jfb2030088
