Design Exploration for Biological Fluid Sampling Platform
Name
higginbotham-hhigginb-ms-me-2024-thesis.pdf
Description
Thesis PDF
Size
8.58 MB
Format
Adobe PDF
Checksum (MD5)
ce999c00a9b18fb6aad1608af2a961aa
Author(s)
Higginbotham, Haley O'Hara
Advisor(s)
Cima, Michael J.
Date Issued
May 2024
Publisher
Massachusetts Institute of Technology
Abstract
This work explores the design of an implantable, peristaltic pumping platform for chronic sampling of neuropeptides. The project drew inspiration from a pumping platform previously developed in the Cima Lab. Users have reported that the previous platform is difficult to use. The pump is also nearly 47x too large to be implanted in rats, which restricts its use to sedated or tethered animals. The project aimed to improve usability and enable implantation. Alternative fluidic junction methods and alternative actuation modes were investigated. The new junction design improves usability by enabling repeated, reversible attachment to the pump. The new, more efficient pump design reduces the pump volume by 49x, enabling implantation.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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