Correlates of protection against SARS-CoV-2 in rhesus macaques
Name
nihms-1649751.pdf
Description
Accepted version
Size
2.28 MB
Format
Adobe PDF
Checksum (MD5)
43961d9b74ab6f1fe5cf1b6448b70da7
Author(s)
McMahan, Katherine
Yu, Jingyou
Mercado, Noe B.
Loos, Carolin
Tostanoski, Lisa H.
Chandrashekar, Abishek
Liu, Jinyan
Peter, Lauren
Atyeo, Caroline
Zhu, Alex Lee
Date Issued
December 2020
Journal
Nature
Publisher
Springer Science and Business Media LLC
Citation
McMahan, Katherine et al. "Correlates of protection against SARS-CoV-2 in rhesus macaques." Nature 590, 7847 (December 2020): 630–634 © 2020 The Author(s).
Version
Author's final manuscript
Abstract
Recent studies have reported the protective efficacy of both natural1 and vaccine-induced2–7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents.
MIT Department
Ragon Institute of MGH, MIT and Harvard
Massachusetts Institute of Technology. Department of Biological Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/s41586-020-03041-6
