Bromonium-Initiated Epoxide-Opening Cascades : total Synthesis of ent-Dioxepandehydrothyrsiferol and Synthetic Studies toward (+)-Scholarisine A
Name
846590192-MIT.pdf
Description
Full printable version
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15.77 MB
Format
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Checksum (MD5)
5b512d9e574b29fccdd675980f632aa4
Author(s)
Tanuwidjaja, Jessica
Advisor(s)
Timothy F. Jamison.
Alternative Title
Total Synthesis of ent-Dioxepandehydrothyrsiferol and Synthetic Studies toward (+)-Scholarisine A
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
CHAPTER I. Bromonium-Initiated Epoxide-Opening Cascades: Total Synthesis of ent-Dioxepandehydrothyrsiferol Our foray into the total synthesis of ent-dioxepandehydrothyrsiferol has led to the discovery and development of the bromonium-initiated epoxide-opening cascade. This transformation constructs the signature trans-anti-trans tricyclic portion of the natural product containing the bromo-oxepane in a single step. Further explorations into this cascade also revealed feasibility of incorporation of exogenous trapping nucleophiles into the reaction. [chemical formulae] CHAPTER 11. Synthetic Studies toward (+)-Scholarisine A. A concise and scalable route toward the monoterpene indole alkaloid (+)- scholarisine A has been developed. Synthetic highlights of the route include: 1) cisselective Diels-Alder cycloaddition reaction to construct strained 5,6-fused hydrindanones, 2) a novel indole formation via an in-situ aza-Wittig reaction, and 3) a selective enolization and hydrolysis sequence of a diketone substrate to provide rapid access to a key tetracyclic intermediate. Studies to access the natural product via latestage intramolecular indole alkylations are presented. [chemical formulae]
Description
Thesis (Ph. D. in Organic Chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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