Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling
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Buchwald_Room Temperatures.pdf
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Author(s)
Buchwald, Stephen Leffler
Senecal, Todd D.
Parsons, Andrew
Date Issued
January 2011
Journal
Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Citation
Buchwald, Stephen Leffler, Andrew T. Parsons, and Todd D. Senecal. "Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling." The Journal of Organic Chemistry 76.4 (2011): 1174-1176.
Version
Author's final manuscript
Abstract
A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/jo1023377
