Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
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polymers-12-02872-v2.pdf
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3.56 MB
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Checksum (MD5)
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Author(s)
Concellon Allueva, Alberto
San Anselmo, María
Hernández-Ainsa, Silvia
Romero, Pilar
Marcos, Mercedes
Serrano, José Luis
Date Issued
November 2020
Journal
Polymers
Publisher
MDPI AG
Citation
Concellón, Alberto et al. "Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties." Polymers 12, 12 (November 2020): 2872 © 2020 The Authors
Version
Final published version
Abstract
The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/polym12122872
