Hippocampal function is not required for the precision of remote place memory
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1756-6606-5-5.pdf
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414.95 KB
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Author(s)
Kitamura, Takashi
Okubo-suzuki, Reiko
Takashima, Noriko
Murayama, Akiko
Hino, Toshiaki
Nishizono, Hirofumi
Kida, Satoshi
Inokuchi, Kaoru
Date Issued
February 2012
Journal
Molecular Brain
Publisher
BioMed Central Ltd
Citation
Kitamura, Takashi et al. “Hippocampal function is not required for the precision of remote place memory.” Molecular Brain 5.1 (2012): 5.
Version
Final published version
Abstract
Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of original place memories also transforms from a precise form to a less precise form with similar time course. The question arises of whether the quality of original place memories is determined by brain regions on which the memory depends. Results: To directly test this idea, we introduced a new procedure: a non-associative place recognition memory test in mice. Combined with genetic and pharmacological approaches, our analyses revealed that place memory is precisely maintained for 28 days, although the recall of place memory shifts from hippocampus-dependent to hippocampus-independent with time. Moreover, the inactivation of the hippocampal function does not inhibit the precision of remote place memory. Conclusion: These results indicate that the quality of place memories is not determined by brain regions on which the memory depends.
MIT Department
Picower Institute for Learning and Memory
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/1756-6606-5-5
