A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols
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Buchwald_A single phosphine.pdf
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Author(s)
Wu, Xiaoxing
Fors, Brett P.
Buchwald, Stephen Leffler
Date Issued
September 2011
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Wu, Xiaoxing, Brett P. Fors, and Stephen L. Buchwald. “A Single Phosphine Ligand Allows Palladium-Catalyzed Intermolecular C-O Bond Formation with Secondary and Primary Alcohols.” Angewandte Chemie International Edition 50, no. 42 (October 10, 2011): 9943-9947.
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Author's final manuscript
Abstract
Forging a bond: An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201104361
