High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane
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i2164-2591-14-1-16_1736855918.59039.pdf
Description
Published version
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1.39 MB
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Checksum (MD5)
7009f2cd7694c1661165eb6200a036f3
Author(s)
Jamil, Muhammad Usman
Won, Jungeun
Ploner, Stefan B
Marmalidou, Anna
Takahashi, Hiroyuki
Kaiser, Stephanie
Hwang, Yunchan
Abu-Qamar, Omar
Yaghy, Antonio
Witkin, Andre J
Date Issued
January 15, 2025
Journal
Translational Vision Science & Technology
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Muhammad Usman Jamil, Jungeun Won, Stefan B. Ploner, Anna Marmalidou, Hiroyuki Takahashi, Stephanie Kaiser, Yunchan Hwang, Omar Abu-Qamar, Antonio Yaghy, Andre J. Witkin, Peter Y. Zhao, Shilpa Desai, Jay S. Duker, Andreas Maier, James G. Fujimoto, Nadia K. Waheed; High-Resolution OCT Reveals Age-Associated Variation in the Region Posterior to the External Limiting Membrane. Trans. Vis. Sci. Tech. 2025;14(1):16.
Version
Final published version
Abstract
Purpose: To evaluate visibility of a sub-band posterior to the external limiting membrane (ELM) and assess its age-associated variation.
Methods: In a retrospective cross-sectional study, normal eyes were imaged using a high-resolution spectral-domain optical coherence tomography (SD-OCT) prototype (2.7-µm axial resolution). Volume fusion of six sequential scans (each 500 × 500 A-scans over 6 mm × 6 mm) was performed in the motion correction and volume reconstruction in OCT (MoReOCT) framework to enhance feature visibility in OCT. The subjects were divided into three groups: young (21-40 years old), middle (41-60 years old), and older (>60 years old). Three expert graders assessed the visibility of the sub-band on B-scans, and its A-scan intensity relative to ELM intensity (peak intensity ratio) was measured.
Results: Forty-four eyes of 44 subjects were imaged. The sub-band, tentatively attributed to the photoreceptor myoid, can be visualized under high-resolution OCT. The B-scan gradings showed that sub-band visibility increased with age (visible in 16.7%, 47.2%, and 66.7% of the young, middle, and older age groups, respectively). The gradings were statistically different among age groups at 1 mm and 2 mm nasal and 1 mm and 2 mm temporal (P < 0.04) from the foveal center. Similarly, the mean peak intensity ratios of the sub-band to the ELM were 71.6%, 77.5%, and 85.2% in the young, middle, and older age groups, respectively, and were positively correlated with age at 1 mm temporal (P = 0.012) and 2 mm temporal (P < 0.001).
Conclusions: High-resolution OCT, combined with advanced volume fusion, enables visualization of the photoreceptor myoid and investigation of its age-associated variations.
Translational Relevance: Investigating the sub-band can advance our understanding of photoreceptors and their association with aging and disease pathogenesis.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1167/tvst.14.1.16
