Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism
Name
Lu-2014-Gut Microbiome.pdf
Size
998.49 KB
Format
Adobe PDF
Checksum (MD5)
032cc059bca0e528af8cbc48486ee54e
Author(s)
Lu, Kun
Mahbub, Ridwan
Cable, Peter Hans
Ru, Hongyu
Parry, Nicola M. A.
Bodnar, Wanda M.
Wishnok, John S.
Styblo, Miroslav
Swenberg, James A.
Fox, James G.
Date Issued
February 2014
Journal
Chemical Research in Toxicology
Publisher
American Chemical Society (ACS)
Citation
Lu, Kun, Ridwan Mahbub, Peter Hans Cable, Hongyu Ru, Nicola M. A. Parry, Wanda M. Bodnar, John S. Wishnok, et al. “Gut Microbiome Phenotypes Driven by Host Genetics Affect Arsenic Metabolism.” Chemical Research in Toxicology 27, no. 2 (February 17, 2014): 172–174. © 2014 American Chemical Society.
Version
Final published version
Abstract
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Division of Comparative Medicine
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/tx400454z
