7.346 DNA Wars: How the Cell Strikes Back to Avoid Disease after Attacks on DNA, Fall 2013
Author(s)
Jordan, Jennifer
Nagel, Zachary
Alternative Title
DNA Wars: How the Cell Strikes Back to Avoid Disease after Attacks on DNA
Date Issued
December 2013
Abstract
A never-ending molecular war takes place in the nucleus of your cells, with DNA damage occurring at a rate of over 20,000 lesions per cell per day. Where does this damage come from, and what are its consequences? What are the differences in the molecular blueprint between individuals who can sustain attacks on DNA and remain healthy compared to those who become sick? This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
DNA damage
DNA repair
mismatch repair
direct reversal
nucleotide excision repair
base excision repair
double strand break repair
nuclear DNA damage
mitochondrial DNA damage
Alkylating agents
replication errors
mutations
epigenetics
base excision repair
Werner helicase activity
MIT Department
Massachusetts Institute of Technology. Department of Biology
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